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10.1016/s0065-3233(08)60546-x 490 PutzeysP.BrosteauxJ

HMs in the soil can have a negative impact on human and animal health, soil quality, fertility, and agricultural productivity

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And you can argue about whether thats good or bad, but youre intervening at the point of the communication instead of at the point of actually creating the abundance

Over multiple cycles, this contributes to: Physical aggregation (clumping) of peptide molecules Potential denaturation of three-dimensional structure Gradual loss of biological activity in research assays The practical solution is simple: aliquot before freezing